American Cleanroom Systems
Request A Quote

About Us

Who We Are

American Cleanroom Systems is a fast reasonably priced design build modular cleanroom company. Experts in ISO-4 thru ISO-8 cleanrooms.

Founded in 1976

Building cleanrooms for more than 50 years. Located in Rancho Santa Margarita, California.

Family Owned

Unlike our corporate and private equity owned competitors, we care about our customers, employees and the local community.

What We Believe

We build cleanrooms, but the thing we really sell is confidence. When your product depends on a controlled environment, you want a partner who picks up the phone, gives you a straight answer, and stands behind the work years after the install is done.

Being family owned shapes how we do that. We are not answering to outside investors or quarterly targets. We answer to the customers who come back to us for their next cleanroom, the employees who have built careers here, and the community we have been part of for decades. That is the standard we hold ourselves to on every project, whether it is 200 square feet or 20,000.

Our stellar record

  • 750 + cleanrooms built
  • 125+ years of cleanroom experience
  • 20+ cleanrooms built for US National Laboratories
  • 15+ cleanroom technical seminars at industry conferences
  • 31+ annual donations to local charities and sponsorships of youth sports teams.

Why American Cleanroom Systems

  • Fast, reasonably priced, and easy to work with, Nationwide installation.
  • Technical expertise: ISO-4 thru ISO-8 cleanrooms, Tight temperature and humidity control, ESD cleanrooms and high bay cleanrooms.
  • In-house manufacturing and factory installation for the highest quality.
  • Our cleanrooms conform to ISO 14644-1 and FED STD 209E cleanroom standards.

What we Build

  • ISO-4 to ISO-8 modular cleanrooms
  • Tight temperature and humidity cleanrooms
  • High Bay cleanrooms
  • Softwall cleanrooms
  • ESD cleanrooms

Proof in the Field

Fast and Efficient: Completed installation of ISO-6 8,095 SF cleanroom in just 12 weeks. Project was 10% under budget and two weeks ahead of schedule.

Technical experts: 4,000 SF class 100 modular cleanroom with plus minus 1 degree temperature control and plus minus 5% humidity control.

Satisfied customers: “We first purchased a cleanroom from you about 5 years ago. At the time, we researched a lot of options and found that your system was the most cost and time effective. For this last round of cleanrooms, I didn’t really look anywhere else.” 

Ryan, Biotech 200 S.F. ISO9, 1,575 S.F. ISO8, and 900 S.F ISO8

Design
Manufacture
Install
Certify

How a cleanroom project works:

  1. Design. We learn what you are making, what classification you need, and what your building allows, then we draw it up.
  2. Manufacture. We build your cleanroom in our own California factory, so we control the quality at every step.
  3. Install. Our own crews handle the install nationwide. Our experienced factory crews are fast and clean.
  4. Certify. We test and certify the room to your required ISO cleanroom class before we hand it over.

Top Tier Qualifications

IEST, ISPE, ISO 14644-1, Made in USA BAA compliant and AVETTA safety registered.

General Contractors license California, General Contractors license Washington, General Contractors license Arizona, General Contractors license Iowa.

Our Team: +125 years of cleanroom expertise and experience:

  • Anthony Chien, President. BS and MS Electrical Engineering University of Illinois, MS Carnegie Mellon University. Leeds Green Associate. Member of IEEE, IEST, and USP797, 30 years of cleanroom experience, and 10 years of experience semiconductor industry.
  • BS Architecture University of California Berkeley, 35 years of cleanroom design and cleanroom construction experience.
  • BS and MS Accounting National University of San Marcos,13 years cleanroom experience.
  • BS University of Indonesia. Accounting Chaffey College, 6 years of cleanroom experience.
  • BS Architecture Bowling Green University, 10 years of construction experience, 3 years of cleanroom design experience, US Marine Corp non-commissioned officer.
  • Job leaders average 20 years of cleanroom construction experience.

Industries we serve

For more than 50 years, American Cleanroom Systems has designed, manufactured, and installed cleanrooms for some of the most demanding industries in the world. Our experience includes:

  • Pharmaceutical Manufacturing
  • Medical Device Manufacturing
  • Biotechnology & Life Sciences
  • Semiconductor & Electronics Manufacturing
  • Aerospace & Defense
  • National Laboratories & Government Research
  • Universities & Research Institutions
  • Industrial Manufacturing
  • Food & Nutraceutical Production
  • USP 797 & USP 800 Compounding Pharmacies
  • CBD & E-Liquid Manufacturing

Whether your project requires an ISO-4 semiconductor cleanroom, a cGMP pharmaceutical facility, a medical device manufacturing environment, or a university research laboratory, our team has the experience to deliver a solution that meets your technical and regulatory requirements.

American Cleanroom Systems has proven itself to a blue chip customer list.

TRUSTED BY FORTUNE 500 & TECHNOLOGY COMPANIES

Apple, Boeing, Google, IBM, Intel, Lockheed Martin, Northrop Grumman, Raytheon, Facebook, Eaton, Kyocera, Bose, Harman Kardon, General Atomics, Flextronics, BAE Systems, and many others.

TRUSTED BY PHARMACEUTICAL & MEDICAL DEVICE COMPANIES

Allergan, Baxter, Bausch + Lomb, Johnson & Johnson, Medtronic, Nephron Pharmaceutical, Providence Health, Regeneron Pharmaceutical, Roche Diagnostics, Siemens Medical, Tissue Bank, Applied Medical, and many others.

TRUSTED BY NATIONAL LABORATORIES & GOVERNMENT AGENCIES

Brookhaven National Laboratory, Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, Los Alamos National Laboratory, Oak Ridge National Laboratory, Sandia National Laboratory, SLAC National Accelerator Laboratory, NASA Cape Canaveral, NASA Jet Propulsion Laboratory (JPL), National Institute of Standards and Technology (NIST), Naval Research Laboratory (NRL), U.S. Army Corps of Engineers, NOAA, and others.

TRUSTED BY UNIVERSITIES & RESEARCH INSTITUTIONS

California Institute of Technology (Caltech), University of California Berkeley, University of California Irvine, Texas A&M University, University of Waterloo, University of Notre Dame, University of Nevada Las Vegas (UNLV), and other leading research institutions throughout North America.

Giving back

Staying in one community for nearly 50 years comes with a responsibility we take to heart. Every year we support local charities and sponsor youth sports teams, 31 and counting at last tally. We have backed programs tied to the US Marine Corps, local schools, and service clubs. It is a small thing next to the work we do for NASA or Apple, but it is the part of the job that keeps us grounded.

Ready to Start

Tell us what you need, and we will get quote back to you in 48 hours. Whether you already have drawings or you are starting from a rough idea, our team will help you land on the right cleanroom for your space, your classification, and your budget.

American Cleanroom Systems® 2026 - Unauthorized use and/or duplication of this material without express and written permission from this website owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to American Cleanrooms with appropriate and specific direction to the original content.

Privacy Policy
 | 
Terms and Conditions
linkedin facebook pinterest youtube rss twitter instagram facebook-blank rss-blank linkedin-blank pinterest youtube twitter instagram