
American Cleanroom Systems is a fast reasonably priced design build modular cleanroom company. Experts in ISO-4 thru ISO-8 cleanrooms.
Building cleanrooms for more than 50 years. Located in Rancho Santa Margarita, California.
Unlike our corporate and private equity owned competitors, we care about our customers, employees and the local community.
We build cleanrooms, but the thing we really sell is confidence. When your product depends on a controlled environment, you want a partner who picks up the phone, gives you a straight answer, and stands behind the work years after the install is done.
Being family owned shapes how we do that. We are not answering to outside investors or quarterly targets. We answer to the customers who come back to us for their next cleanroom, the employees who have built careers here, and the community we have been part of for decades. That is the standard we hold ourselves to on every project, whether it is 200 square feet or 20,000.






Fast and Efficient: Completed installation of ISO-6 8,095 SF cleanroom in just 12 weeks. Project was 10% under budget and two weeks ahead of schedule.
Technical experts: 4,000 SF class 100 modular cleanroom with plus minus 1 degree temperature control and plus minus 5% humidity control.
Satisfied customers: “We first purchased a cleanroom from you about 5 years ago. At the time, we researched a lot of options and found that your system was the most cost and time effective. For this last round of cleanrooms, I didn’t really look anywhere else.”
Ryan, Biotech 200 S.F. ISO9, 1,575 S.F. ISO8, and 900 S.F ISO8








IEST, ISPE, ISO 14644-1, Made in USA BAA compliant and AVETTA safety registered.





General Contractors license California, General Contractors license Washington, General Contractors license Arizona, General Contractors license Iowa.









For more than 50 years, American Cleanroom Systems has designed, manufactured, and installed cleanrooms for some of the most demanding industries in the world. Our experience includes:
Whether your project requires an ISO-4 semiconductor cleanroom, a cGMP pharmaceutical facility, a medical device manufacturing environment, or a university research laboratory, our team has the experience to deliver a solution that meets your technical and regulatory requirements.
TRUSTED BY FORTUNE 500 & TECHNOLOGY COMPANIES
Apple, Boeing, Google, IBM, Intel, Lockheed Martin, Northrop Grumman, Raytheon, Facebook, Eaton, Kyocera, Bose, Harman Kardon, General Atomics, Flextronics, BAE Systems, and many others.
TRUSTED BY PHARMACEUTICAL & MEDICAL DEVICE COMPANIES
Allergan, Baxter, Bausch + Lomb, Johnson & Johnson, Medtronic, Nephron Pharmaceutical, Providence Health, Regeneron Pharmaceutical, Roche Diagnostics, Siemens Medical, Tissue Bank, Applied Medical, and many others.
TRUSTED BY NATIONAL LABORATORIES & GOVERNMENT AGENCIES
Brookhaven National Laboratory, Lawrence Berkeley National Laboratory, Lawrence Livermore National Laboratory, Los Alamos National Laboratory, Oak Ridge National Laboratory, Sandia National Laboratory, SLAC National Accelerator Laboratory, NASA Cape Canaveral, NASA Jet Propulsion Laboratory (JPL), National Institute of Standards and Technology (NIST), Naval Research Laboratory (NRL), U.S. Army Corps of Engineers, NOAA, and others.
TRUSTED BY UNIVERSITIES & RESEARCH INSTITUTIONS
California Institute of Technology (Caltech), University of California Berkeley, University of California Irvine, Texas A&M University, University of Waterloo, University of Notre Dame, University of Nevada Las Vegas (UNLV), and other leading research institutions throughout North America.

Staying in one community for nearly 50 years comes with a responsibility we take to heart. Every year we support local charities and sponsor youth sports teams, 31 and counting at last tally. We have backed programs tied to the US Marine Corps, local schools, and service clubs. It is a small thing next to the work we do for NASA or Apple, but it is the part of the job that keeps us grounded.

Tell us what you need, and we will get quote back to you in 48 hours. Whether you already have drawings or you are starting from a rough idea, our team will help you land on the right cleanroom for your space, your classification, and your budget.
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