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What is a Hybrid Cleanroom?

julio 11, 2023
Figure 1. Hybrid cleanroom – modular and standard constructions. ISO-7 laser cleanroom.

A hybrid cleanroom is a cleanroom that uses multiple cleanroom wall systems. Hybrid cleanroom systems are often used to reduce project cost by utilizing existing standard construction walls.  Cleanroom wall systems that are often used include: modular cleanroom walls, standard construction cleanroom walls, and clear vinyl softwall material.

Modular walls offer quick, clean construction, an easy way to expand an existing standard construction cleanroom. Applications include modular dividing walls, return air walls, and addition of ante room or gown rooms.

Figure 2. Hybrid cleanroom - Modular gown room added onto existing standard construction cleanroom. ISO-6 Pharmaceutical cleanroom.

Epoxy painting existing standard construction walls and adding new modular walls can save customer money in construction of new cleanroom.

Figure 3. ISO-7 medical device hybrid cleanroom – utilizing new modular and existing standard construction cleanroom walls

In some applications – clear vinyl softwall can be used to create ISO-8 hybrid cleanrooms. These rooms are typically one pass design. Advantages include lower cost and quick installation. Disadvantages include no measurable positive pressure, these rooms are restricted to one pass design,  and these rooms can only be used for lower cleanroom classifications.

Figure 4. Hybrid cleanroom – standard build and softwall. ISO-8 Biotech cleanroom

Sometimes softwall dividers are used in modular cleanrooms to segregate air flow but still allow operator visibility into other area, thus creating a hybrid cleanroom.

Figure 5: Hybrid cleanroom using modular and softwall. ISO-5 Pharmaceutical cleanroom.

In food cleanrooms, it is common to a clear vinyl strip curtain wall to allow operators to easily move pallets of product into and out of cleanroom. These cleanrooms are typically ISO-8 one pass. The modular walls are easier to clean and give better particle control than a 100% softwall cleanroom. 

Figure 6. ISO-8 Hybrid cleanroom – modular and softwall. Food cleanroom.

Summary: Hybrid cleanrooms are cleanrooms built combining multiple wall systems including modular cleanroom wall systems, standard construction walls and clear vinyl softwall.  Advantages of hybrid cleanrooms are lower cost and quicker installation. Common applications are cleanroom dividing walls, return air walls, or addition of ante-rooms or gown rooms. Hybrid cleanrooms are typically only used for lower class cleanrooms.

Property American Cleanroom Systems 2023

The author Anthony Chien has worked at American Cleanroom Systems for more than 10 years . He has more than 40 years of cleanroom experience. Anthony has a BS and MS in Electrical Engineering specializing in semiconductor manufacturing from the University of Illinois. American Cleanroom Systems is a design build modular cleanroom manufacturer based in Rancho Santa Margarita CA. It is expert in ISO-5 thru ISO-8 (class 100 to class 100k) modular cleanrooms for nutraceutical cleanrooms, pharmaceutical cleanrooms, medical device cleanrooms, and industrial cleanrooms.
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