American Cleanroom Systems
Solicitar Presupuesto

Cleanroom Fan Filter Units vs Air Handling Units

enero 12, 2023

Most cleanrooms today are built with HEPA fan filter units in ceiling to provide air filtration for cleanroom class. The advantages of the negative pressure plenum design modular cleanrooms over the old Air Handling units ducted cleanroom design include lower cost, easier install, more robust, and easier to upgrade.

2x4 HEPA fan filter unit, aluminum rectangular body
Figure 1. 2x4 HEPA fan filter unit used in cleanrooms
modular cleanroom ceiling, white HEPA fan filter units in cleanroom ceiling
Figure 2. HEPA fan filter units in ceiling of cleanroom
air flow diagram for recirculating modular cleanroom, HEPA fan filter units in plenum
Figure 3. Air flow diagram recirculating modular cleanroom using HEPA fan filter units

Advantages of using HEPA fan filter units in a negative pressure plenum:

  • Lower cost. Elimination of long lead time expensive custom air handlers. The HEPA fan filter unit provides the filtered air movement so lower cost short lead time commercial HVAC DX systems can be used to cool the cleanroom.
  • Easier installation and less maintenance: Each HEPA fan filter unit has its own fan pushing ~ 600 CFM of HEPA filtered air locally, eliminating the problem of balancing HEPA air flow for long cleanroom duct runs.
  • More robust: The cleanroom is not dependent on single piece of custom equipment (air handler) for filtration air flow. If a HEPA fan filter unit fails the other HEPA fan filter units in the cleanroom will continue to provide HEPA filtered air. The failed HEPA fan filter unit is easily replaced.
  • Lower cost: There is no need for ducting to each HEPA fan filter unit. The air easily flows thru the cleanroom plenum to each unit.
  • Easy to Upgrade: The cleanroom can be easily upgraded to higher cleanroom classification by adding more HEPA fan filter units into plenum and more return air walls
  • Options: special variants of HEPA fan filter units for cleanrooms include
    • ULPA filters
    • Room side replaceable filters
    • 2’x2’, 2’x4’ and 4’x4’ size
    • Energy saving DC motors
    • Test ports
    • Indictor lights
1980’s ducted cleanroom design, air handler unit, ducted HEPA filters
Figure 4. 1980’s circa cleanroom with custom air handler and ducted ceiling module HEPA filters

Disadvantages of air handler based ducted cleanrooms:

  • Long lead times and high cost for custom cleanroom air handler units to drive high air volume thru HEPA filters. Standard commercial air handlers will not work.
  • Hard to get air to flow evenly to HEPA filters long distance from air handler
  • Cleanroom Air handler is single point of failure
  • Cleanroom requires frequent balancing
  • Cost of ducting to each HEPA filter
  • Very expensive and difficult to upgrade cleanroom class

Situations where air handler based ducted HEPA filter cleanrooms still used:

  • Hazard chemical cleanrooms where explosion risk dictates that electric motors be located away from air stream
  • Tight temperature tolerance cleanrooms (+1 F) where the temperature of the air can be affected by presence of electric motors in HEPA fan filter units
  • Non critical ISO-8 cleanrooms where single HEPA filter can be placed in Air Handler. The Air Handler must be custom designed for correct CFM and static pressure drop


Most cleanrooms today are built with HEPA fan filter units in ceiling to provide air filtration for cleanroom class. The advantages of the negative pressure plenum design modular cleanrooms over the old Air Handling units ducted cleanroom design include lower cost, easier install, more robust, and easier to upgrade. There are still some circumstances where air handler unit centric ducted HEPA filtration is used.

Property American Cleanroom Systems 2023

The author Anthony Chien has worked at American Cleanroom Systems for past 10 years. He has more than 40 years of cleanroom experience. Anthony has a BS and MS in Electrical Engineering specializing in semiconductor manufacturing from the University of Illinois. American Cleanroom Systems is a design build modular cleanroom manufacturer based in Rancho Santa Margarita CA. It is expert in ISO-5 thru ISO-8 (class 100 to class 100k) modular cleanrooms for pharmaceutical cleanrooms, medical device cleanrooms, and industrial cleanrooms.

Blog Posts

What is a Cleanroom Interlock?

All About Cleanroom Curtains and Strip Curtains

Difference Between Cleanroom Bench and Cleanroom Fume Hoods

All About Softwall Cleanrooms

All About Cleanroom Air Change Rates

All About LED Cleanroom Ceiling Lights

Stainless Steel in Cleanrooms - Which is the Best Grade?

All About Nutraceutical Cleanrooms

Differential Pressure in Cleanrooms Explained

Semiconductor Cleanrooms 101

Pass Thru Chambers in Cleanrooms

What is an ISO-5 Cleanroom Classification?

HEPA vs. ULPA Filters

Top Seven Cleanroom Design Mistakes

All About Cleanroom Walls

Cleanroom vs. Controlled Environment

How Do Cleanroom Air Showers Work?

What is an ISO-7 Cleanroom Classification?

All About Food Cleanrooms

What is Cleanroom Lighting?

All About Cleanroom Furniture

All About Cleanroom Sprinklers

Cleanroom 101

Cleanroom Gowning Levels

ESD Environment Considerations for Cleanrooms

How the 2022 Chips Act Can Pay for Cleanrooms

GMP vs cGMP in Cleanrooms: What’s the Difference?

Explanation of Cleanroom Water Systems

All About Cleanroom Flooring

Top 5 Cleanroom Design Tips For Industrial Cleanrooms

One Pass Cleanroom vs. Recirculating Cleanroom

How to Select The Best Cleanroom Particle Counter

What Is An ISO-8 Cleanroom Classification?

5 Reasons to Purchase a Turnkey Complete Cleanroom

10 Tips on Choosing a Building for a Cleanroom

Building a Mask Manufacturing Cleanroom

Cleanroom Installation: What to Expect

What Are My Choices For Cleanroom Doors

Modular Cleanrooms vs. Standard Construction Cleanrooms

Modular vs. Softwall Cleanroom Systems

Eight Tips To Expedite Your Cleanroom Design Build

View All Posts

Cuarto Limpio

American Cleanroom Systems

Necesita una Cuarto Limpio ahora?

Cotizaciones en 48 horas. Llame o complete el formulario de solicitud de presupuesto en línea.

Solicitar Presupuesto
23221 Arroyo Vista Rancho Santa Margarita California, 92688

American Cleanroom Systems® 2023 - Unauthorized use and/or duplication of this material without express and written permission from this website owner is strictly prohibited. Excerpts and links may be used, provided that full and clear credit is given to American Cleanrooms with appropriate and specific direction to the original content.

Política de privacidad
Terms and Conditions